Foster Delivery Science is a contract manufacturing firm specializing in hot melt extrusion of active pharmaceutical ingredients and polymers for highly regulated applications including oral solid dosage and implantable drug/device combination products.
Our inventory of downstream processing equipment is specifically designed for the manufacturing of customized dosage forms including pellets, tablets, transdermal & transmucosal films, monofilaments, bioresorbable and biodurable implants and capsule filling.
Alternative Process for Solid Dispersions
Compared to solvent processes aiming at solid molecular dispersions, hot melt extrusion technology offers a promising alternative. The polymer/drug blend is melted and extruded, which de-aggregates the API into small particles or dissolves the API within the polymer matrix on a molecular level. This technology is suitable for both high dose and potent compounds and has been proven to provide sustained, modified, and targeted drug delivery.
Foster Delivery Science provides contract services for the development and manufacturing of implantable drug delivery devices. These drug/device combination products can be comprised of either resorbable or non-resorbable polymers and include finished devices such as implantable dosage forms or novel structures to elute your API for local drug delivery.
Localized forms of drug delivery offer unique benefits of increased local bioavailability with decreased adverse events associated with systemic alternatives. Drug delivery in this form also offers controlled release at the designated site over an extended period.
Resorbable Implant Delivery
Foster Delivery Science can blend bioresorbable polymers and compatible active pharmaceutical ingredients to provide precise drug delivery via implantable devices that will resorb over time. These customized blends can be extruded into fiber or film, or injection molded to meet specific application requirements.
Processed via thermoplastic melt blending technology, bioresorbable materials used in drug/device combination products can be selectively enhanced through molecular weight variation and / or copolymerization. These formulations can offer a wide range of physical properties and degradation characteristics and can be designed to contain active pharmaceutical ingredients.
Temporary – Long Term Implant Delivery
Local or systemic drug delivery can be achieved with temporary implants in which active pharmaceutical ingredients (APIs) are blended with biodurable (non-resorbing) polymers. The use of a biodurable polymer allows the implant to be removed at any point during the implantation period in the occurrence of an adverse event and at the conclusion of therapy.
Ethylene vinyl acetate (EVA) is the most common polymer of choice for many temporary implant delivery systems. This copolymer, comprised of ethylene and vinyl acetate, has a low melting temperature which allows for blending without degradation of selective APIs. High flexibility and elongation of EVA reduces patient discomfort for implantable applications.